Survival Rate For Burkitt's Lymphoma
There are several types and different stages of maturation for these cells. 3, the endemic variant (also called "African variant most commonly occurs in children living in malaria endemic regions of the world (e.g., equatorial Africa, Brazil, and, papua New Guinea ). 11 MiRNAs influence B cell maturation, generation of pre-, marginal zone, follicular, B1, plasma and memory B cells. Hagerstown, MD: Lippincott Williams Wilkins. It was not until 3 years later that the tumors were histologically identified by Burkitt and OConor as malignant lymphomas.
few days to weeks. The sporadic type of Burkitt lymphoma (also known as "non-African is the most common variant found in places where malaria is not holoendemic. Ethical approval Ethical approval for this study was obtained from the Health Research Ethics Committee of the University of Stellenbosch; ethics reference number N11/03/100. Only 50 of these patients survived.
The peculiar epidemiology of BL showed that the endemic type was mainly confined to equatorial Africa and has a very close association with the EpsteinBarr virus (EBV with approximately 95 of the endemic cases showing the presence of the EBV genome in their tumour cells. Lyon, France : International Agency for Research on Cancer. Adverse effects of the treatment were recorded. Our study analyzed possible differences related to BL and ethnicity and found that all ethnic groups presented predominantly with abdominal tumours.
Their age ranged from 2 test to 14 years (mean.8 years).The male to female ratio was.6/1. 0302, (accessed last 31 December 2013 (Mid- year population estimates 2013) Emmanuel B, Kawira E, Ogwang MD, Wabinga H, Magatti J, Nkrumah F, Neequaye J, Bhatia K, Brubaker G, Biggar RJ, Mbulaiteye amazon SM: Age-specific risk and correlations with malaria biomarkers. 4, non-Hodgkin lymphoma, which includes Burkitt's, accounts for 3050 of childhood lymphoma. Harrisons principles of internal medicine.
PubMed View Article Google Scholar Burkitt. Determining the climatic limitations of a childrens cancer common in Africa.
The socioeconomic status had no influence on the incidence of survival the tumour. The manager of Tygerberg Hospital approved the retrieval of data from the Tygerberg Hospital folders. As South Africa is a sale diverse Country with multiple population groups with different ethnic and cultural background, the demographics of the patients that were included in this study reflect largely the greater population of the Western Cape (predominantly a coloured population.9 followed by the. "Burkitt's lymphoma: new insights into molecular pathogenesis".
The CD4 count ranged from 304 to 1194 with a mean of 612 and median of 394.
All ethnic groups predominantly presented with abdominal involvement.
The old descriptive term of "small non-cleaved cell" is misleading.
The outlook for each child is specific to their circumstances. The translocations that occur in Burkitts lymphoma may be of the t(8;14 t(8;2) or t(8;22) type. The LMB treatment protocol has a good outcome but is complicated by significant morbidity.
The literature is controversial with regard to the predominance of the other two forms, endemic and sporadic BL, in children: older studies published found that patients closely resembled endemic BL while more recent literature indicates that children present the sporadic variant. This is different and unique to the rest of South Africa which has a predominant black population. Some of the children had computerized tomography scans. The ileocecal region is the common site of involvement. The initial presenting tumour site was abdominal in most cases (76.4). As treatments are improving over time, children who are now being diagnosed with NHL may have a better outlook than these statistics show.
In our study, ethnicity had no significant effect on the site of the primary tumour. Progression of Burkitts lymphoma, burkitts lymphoma is the most aggressive subtype of NHL. Authors Affiliations (1) Department of Paediatrics and Child Health, Tygerberg Hospital and Stellenbosch University References Magrath I: Epidemiology: clues to the pathogenesis of Burkitt lymphoma. Many patients reside in very dry, and relatively colder climates where the temperature drops below 15C (60F showing a marked difference from the endemic BL climate pattern, where the average temperature ranges between 18-27C with a humidity of 30 or higher.